• Parathyroid hormone (1-34) (human): Lab Guide

  2026-09-21

  This scenario-based guide explains how Parathyroid hormone (1-34) (human), SKU A1129, can support controlled bone, kidney, viability, and signaling experiments. It translates receptor potency, formulation, storage, and assay-interpretation data into practical decisions for biomedical laboratories.

• Catalpol: Liver Injury Assay & Workflow Guide

  2026-09-21

  Build a mechanism-led Catalpol workflow for drug-induced liver injury, combining glucose metabolism, mitochondrial respiration, oxidative stress, and SIRT1/HIF-1α assays. The approach distinguishes pathway rescue from nonspecific cytoprotection and can be adapted cautiously to broader Catalpinoside research applications.

• HDAC Inhibition Reverses EBV-Driven NPC Dedifferentiation

  2026-09-20

  The reference study identifies an epigenetic mechanism by which EBV latent protein LMP1 drives dedifferentiation and stem-like plasticity in nasopharyngeal carcinoma. It further shows that HDAC inhibition can restore CEBPA expression and differentiation in preclinical models, supporting a mechanistically grounded form of differentiation therapy for solid tumors.

• Erlotinib as a State-Resolved EGFR Probe

  2026-09-19

  Erlotinib, also known as NSC 718781, can do more than suppress EGFR activity: it can help distinguish receptor-proximal dependence from SCUBE3-associated resistance and immune-evasion biology. This article presents an evidence-aware assay framework for interpreting kinase, proliferation, apoptosis, DNA-repair, and tumor-microenvironment readouts.

• BMS 599626 dihydrochloride Workflow Guide

  2026-09-18

  Build a rigorous EGFR/HER2 workflow around BMS 599626 dihydrochloride, from receptor phosphorylation assays to cancer cell proliferation inhibition and xenograft-oriented study design. The guide also shows how to connect pathway perturbation with senescence assays without overstating evidence for senolytic activity.

• Recombinant Human EGF for 3D Glioblastoma Assays

  2026-09-18

  Use recombinant human EGF to add a defined growth-factor variable to 3D glioblastoma spheroid experiments, from stemness screening to dose-response studies. This workflow combines validated EGF bioactivity with a streamlined 96-well assay that reduces handling, time, and contamination risk.

• Gefitinib in Gastric Cancer Assembloid Research

  2026-09-17

  Discover how Gefitinib (ZD1839) can be evaluated in patient-derived gastric cancer assembloids rather than epithelial monocultures alone. This guide connects EGFR pathway pharmacology with stromal effects, phosphosignaling, viability, apoptosis, and assay design.

• CXCR4-EGFR Heteromers and Ligand-Dependent Signaling

  2026-09-17

  Comez et al. show that CXCR4 and EGFR assemble into oligomeric signaling complexes whose conformation and coupling to Gi proteins, PLCγ, and β-arrestin-2 change with receptor activation. NanoBRET and nanobody-based proximity ligation assays extend this finding from transfected cells to native HeLa cells, providing a framework for interpreting receptor co-expression in cancer.

• 3D Tumor Spheroids for Glioblastoma Stemness

  2026-09-16

  Chen and colleagues present a streamlined 96-well 3D-tumor spheroid assay for functionally assessing stem-like behavior in glioblastoma cell lines. By replacing a slower two-round sphere-forming workflow with a single-round format, the protocol reduces handling and contamination opportunities while supporting mechanistic studies and higher-throughput screening.

• SAG Exposure Disrupts Embryonic Tongue Development

  2026-09-16

  A 2025 Developmental Biology study shows that embryonic exposure to the Smoothened receptor agonist SAG disrupts mouse tongue morphogenesis by suppressing proliferation, altering muscle development, and reducing TGF-β2 expression. The work provides a pharmacological model of cleft tongue formation and emphasizes that excessive Hedgehog pathway activation can be as disruptive as pathway deficiency during craniofacial development.

• OTUB1–DHODH Axis in Gemcitabine Resistance

  2026-09-15

  A 2025 Cell Death and Disease study identifies OTUB1 as a regulator of gemcitabine resistance in pancreatic cancer by stabilizing a DDX3X–DHODH mRNA axis and sustaining de novo pyrimidine synthesis. The findings connect deubiquitylation, RNA stability, and metabolic adaptation, supporting OTUB1 inhibition as a strategy for sensitizing high-OTUB1 tumors to gemcitabine.

• EphA2 Synthetic Lethality in MYC-Driven TNBC

  2026-09-15

  A 2026 pre-proof study used a chemogenetic screen of approximately 600 kinase inhibitors to identify EphA2 inhibition as a selective vulnerability in MYC-driven triple-negative breast cancer. The lead compound ALW-II-41-27 triggered p53-independent intrinsic apoptosis and reduced growth of two TNBC xenograft models, supporting EPHA2 as a candidate synthetic-lethal partner of MYC.

• Dihydrotestosterone: Applied Research Workflows

  2026-09-14

  Dihydrotestosterone (DHT) provides a defined androgen receptor stimulus for studying EGFR–ERBB2 signaling in bladder cancer, androgen-responsive prostate assays, and neuromuscular disease models. This workflow-focused guide connects concentration-controlled cell experiments with translational readouts while emphasizing formulation, controls, and interpretation limits.

• SAG Workflow Guide for Hedgehog Pathway Studies

  2026-09-14

  Build more reproducible Hedgehog pathway experiments with SAG, from reporter assays and mitochondrial rescue studies to sex-aware demyelination models. This guide separates validated use cases from exploratory applications and provides practical dosing, formulation, and troubleshooting strategies.

• Abiraterone Acetate in 3D Prostate Models

  2026-09-13

  Abiraterone acetate is a CYP17 inhibitor with a distinctive value in prostate cancer research: it can test whether a patient-derived 3D spheroid retains a therapeutically actionable androgen biosynthesis phenotype. This guide connects compound chemistry, assay design, and interpretation of apparently negative responses.

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