• N1-Methyl-Pseudouridine-5'-Triphosphate: Mechanistic Insi...

  2025-09-22

  Explore how N1-Methyl-Pseudouridine-5'-Triphosphate advances RNA synthesis and translation fidelity, offering critical benefits for mRNA vaccine development and RNA stability enhancement. This review provides mechanistic analyses and practical considerations for its use in research.

• PD 0332991 (Palbociclib) HCl: Mechanistic Advances in CDK...

  2025-09-19

  Explore the latest mechanistic insights into PD 0332991 (Palbociclib) HCl as a selective CDK4/6 inhibitor, focusing on its ability to induce cell cycle G1 phase arrest and novel apoptotic signaling pathways relevant to breast cancer and multiple myeloma research.

• Fluorescent RNA Probe Synthesis with HyperScribe™ T7 Cy3 Kit

  2025-09-18

  Explore the advanced methodology of fluorescent RNA probe synthesis using the HyperScribe T7 High Yield Cy3 RNA Labeling Kit for high-sensitivity in vitro transcription RNA labeling, enabling robust applications in gene expression analysis and hybridization assays.

• ALK fusion positive NSCLC is clinically actionable because

  2025-03-03

  

  ALK fusion-positive NSCLC is clinically actionable because it can be targeted by several FDA-approved drugs, including the first generation TKI crizotinib, which is a dual inhibitor to MET and ALK [15], and the second generation inhibitors, alectinib and ceritinib, both of which are highly-selective

• In addition to it we also showed that glycine increases

  2025-03-03

  

  In addition to it, we also showed that glycine increases miR-301a expression which directly binds to PTEN 3′UTR target sites [13]. Glycine confers neuroprotection through microRNA-301a/PTEN signaling in rats cortical neurons in oxygen deprivation model [13]. Substantial studies indicate that inhibit

• Implicit in this concept is the

  2025-03-03

  

  Implicit in this concept is the idea that the β-adrenoceptors in the detrusor would be activated by adrenergic nerves of the sympathetic system: sympathetic activity promoting relaxation and enhancing bladder capacity. However, it has been demonstrated that there is only a sparse adrenergic innervat

• br Experimental procedures br Results br Discussion br Ackno

  2025-03-03

  

  Experimental procedures Results Discussion Acknowledgments Introduction β-Adrenergic receptors (β-ARs) belong to the superfamily of membrane proteins termed G protein-coupled receptors. β-ARs are distributed in the effector Gallein structure of most of the sympathetic nerve fibers, a

• Besides its multiple peripheral effects adiponectin may amel

  2025-03-03

  

  Besides its multiple peripheral effects adiponectin may ameliorate insulin resistance by acting in the brain, and intracerebroventricular administration of adiponectin in rodents decreases body weight by stimulating energy expenditure [13]. Adiponectin most likely crosses the blood-CSF-barrier (BCB)

• We further analyzed selected hit compounds for their ability

  2025-03-03

  

  We further analyzed selected hit compounds for their ability to inhibit human AdK in intact cells. Human 1321N1 astrocytoma adrenergic antagonist were utilized which were found to express AdK. The whole cell assay was performed using a 96-well format. The standard AdK inhibitor 5-iodotubercidin was

• br Introduction Adenosine deaminase ADA which can catalyze

  2025-03-03

  

  Introduction Adenosine deaminase (ADA), which can catalyze the conversion of AD to inosine by removing an amino group, is a key hydrolytic enzyme of purine metabolism (Conway and Cooke, 1939), and plays an important role in an amount of diseases. For example, an increase of ADA activity in serum

• Macrophage polarization is linked to activation of the ligan

  2025-03-03

  

  Macrophage polarization is linked to activation of the ligand-dependent transcription factor PPARγ. Recently, Odegaard et al. demonstrated with a macrophage-specific deletion of PPARγ in mice that alternative macrophage activation is impaired [14]. We provided evidence that contact to apoptotic dfmo

• In the final set of experiments the dependence

  2025-03-03

  

  In the final set of experiments, the dependence of the reaction rate on viscosity was determined. The experimental protocol previously used to study the reaction of LOX with AA was used., Reactions of 5-LOX and AA were carried out at different relative viscosities in Tris buffer (25mM, pH 8.0) at 2

• br Acknowledgments br Introduction Hypospadias is a common c

  2025-03-03

  

  Acknowledgments Introduction Hypospadias is a common congenital malformation in males, in which the urethral orifice is found on the ventral side of the penis as a result of incomplete fusion of urethral folds. The mean prevalence in per 10,000 live births from 1910 to 2013 were: Europe 19.9,

• br Autophagy and antiviral innate immunity signaling br Vira

  2025-03-03

  

  Autophagy and antiviral innate immunity signaling Viral manipulation of autophagy interfering with IFN-I synthesis We have seen that autophagy factors can down-regulate the production of IFN-I induced by RLR engagement during viral infection. In fibroblasts and epithelial cells, there exists c

• Although CP has been an important research subject

  2025-03-03

  

  Although CP has been an important research subject in the field of antigen processing and presentation, the mechanisms of presentation of intracellular LJH685 by MHC II received considerably less attention. Interestingly, pioneering work by the Münz laboratory has pointed to an involvement of autop

15398 records 1/1027 page Next 12345 下5页 Last page