• Next to their indirect effect on ASBT expression microbiota

  2022-05-18

  

  Next to their indirect effect on ASBT expression, microbiota are also directly involved in BA homeostasis and FXR-FGF15/19 signaling. Different species of intestinal microbiota have the ability to biotransform BAs mainly by deconjugation and subsequent de-hydroxylation, the latter resulting in more

• Several studies have shown that the levels

  2022-05-18

  

  Several studies have shown that the levels of reactive dicarbonyls are higher in patients with diabetes as a result of hyperglycemia.49, 50, 51 Consequently, reactive dicarbonyl-derived AGEs are elevated in plasma and accumulate in tissues prone to secondary complications, including the lens, retina

• Ubiquitination of GlyRs subunit on plasma membrane has been

  2022-05-18

  

  Ubiquitination of GlyRs-α1 subunit on plasma membrane has been shown to initiate the receptor 486 2 and subsequent degradation in lysosomes (Buttner et al., 2001). However, the specific E3 ligase responsible for GlyRs-α1 ubiquitination is largely unknown as yet. Also, the functional consequence of

• This data is in accordance with our

  2022-05-18

  

  This data is in accordance with our recent results on the influence of cholesterol-depleting agent methyl-β-cyclodextrin on platelets (Borisova et al., 2011a). Dissipation of the proton electrochemical gradient of secretory granules by methyl-β-cyclodextrin did not evoke the release of endogenous gl

• Although EAAT may not be involved in

  2022-05-18

  

  Although EAAT3 may not be involved in the induction of morphine-induced CPP, our results suggest that other EAATs may play a role in the behavior because riluzole, an EAAT activator (Frizzo et al., 2004, Fumagalli et al., 2008), abolished morphine-induced CPP. Consistent with this suggestion, a few

• Axons are the largest component of

  2022-05-18

  

  Axons are the largest component of WM by volume and are a significant repository of intracellular glutamate that can be releases under ischemic conditions [1,3,4,29,117]. We have recently shown that the principle route by which mature myelinated Senexin A release glutamate during acute ischemia is v

• br Experimental br Results and discussions br Conclusion br

  2022-05-17

  

  Experimental Results and discussions Conclusion Notes Introduction The noncanonical DNA structures that is, i-motif [[1], [2], [3], [4], [5], [6], [7], [8], [9]] and G-quadruplex [[10], [11], [12], [13], [14]] have recently been carefully studied using either experimental or computati

• Studies have indicated that formylated peptides FPRs and

  2022-05-17

  

  Studies have indicated that formylated peptides, FPRs, and in particular FPR-1 may be principal conductors in inflammatory processes in sterile-24, 26 and infection-related diseases. FPR-1 and formylated peptides, which are active components of CS, have been involved in smoking-induced lung damage,

• Sumoylation is involved in regulating protein protein intera

  2022-05-17

  

  Sumoylation is involved in regulating protein-protein interactions, subcellular protein localization, protein stability, and transcriptional factor activity (reviewed in [29]). The small ubiquitin-like modifier (SUMO) protein is covalently attached to a lysine residue in a Ψ-K-X-D/E consensus sequen

• Pertussis Toxin Our biological data also showed that in pres

  2022-05-17

  

  Our biological data also showed that, in presence of LEDGF/p75, R or S of glycerol T instead of T4, T8 or T12 loop in the T30695-GQ differently affected the integration activity of the enzyme (Table 2), whereas the position but not the chirality of glycerol T affected the inhibitory efficiency of T3

• The possibility of having false positives even if

  2022-05-17

  

  The possibility of having false positives, even if minimized, is always present and requires that a reactive result should be followed by a confirmation test. Traditionally, Western blot (WB) has been used, but various types of immunoblotting that use recombinant Endomorphin-1 australia or syntheti

• Allergic rhinitis characterized by inflammation of

  2022-05-17

  

  Allergic rhinitis, characterized by inflammation of the nasal membrane, results from an over-activated immune system exposed to (-)-Huperzine A in sensitized individuals, and is associated with nasal congestion, rhinorrhea, sneezing, and pruritus. As histamine is a key mediator in triggering allergi

• Bile acids synthesized in the

  2022-05-17

  

  Bile acids synthesized in the liver are secreted into the intestinal tract to facilitate the digestion and acetylcholine chloride of nutrients. Most bile acids are reabsorbed by the ileum and are transported back to the liver via the portal blood circulation. Recently, bile acids have also been con

• Priming phosphorylation can also generate a binding site for

  2022-05-17

  

  Priming wehi can also generate a binding site for some protein-interaction domains and adaptor proteins that recruit kinases to phosphorylate more distal sites [36]. Well-characterized phosphoprotein-interacting domains include pTyr-binding SH2 domains present in many nonreceptor TyrKs and the pSer/

• We have shown previously that

  2022-05-17

  

  We have shown previously that activation of the TGFβ/Smad signaling pathway in keratinocytes regulates BYL719 cytoskeleton organization via non-genomic and genomic mechanisms and that RhoB gene is a target of Smad proteins [12,13]. Although the role of RhoB in early non-genomic TGFβ-induced cell re

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