Recent research suggests that NSCs tropism

2018-10-20

Recent research suggests that NSCs\' tropism towards neoplastic areas is driven by chemoattractants produced at the tumor site. The intratumoral hypoxic microenvironment activates SDF-1/CXCR4 and VEGF/VEGFR signaling pathways, which may act as downstream effectors to increase NSC tropism (Aboody et

XCI is required for dosage compensation

2018-10-20

XCI is required for dosage compensation of X-linked genes in mammals (Lyon, 1961). In humans, the initiation of XCI is dependent on the X inactivation center, and the X inactive specific transcript (XIST) is a critical gene in this region, which produces a non-coding RNA and coats the X chromosome i

br Materials and methods br Results br

2018-10-20

Materials and methods Results Discussion We have identified and begun to characterize a novel miRNA, miR-410, which on inhibition of BMP signaling by Noggin, is down-regulated in the adult SVZ. Over-expression of miR-410 in SVZ neurospheres inhibited neuronal differentiation and increased t

sphk Although the central nervous system is relatively immun

2018-10-20

Although the central nervous system is relatively immunotolerant (Barker and Billingham, 1977) and human fetus-derived NS/PCs and hESC-derived NS/PCs (hESC-NS/PCs) showed weak immunogenicity (Odeberg et al., 2005; Åkesson et al., 2009; Liu et al., 2013a), no studies to date have investigated the ext

A recent study indicated that

2018-10-20

A recent study indicated that XIST expression can be lost upon prolonged passaging of female hiPSCs, referred to as “erosion of XCI” (Mekhoubad et al., 2012). This epigenetic erosion was found to be irreversible and correlated with a loss of differentiation characteristics and is very relevant for d

br Results br Discussion The first

2018-10-20

Results Discussion The first objective of this study was the definition of an optimal protocol for MSC isolation. We intentionally focused on BM and AT, as these are the most accessible tissues for MSC recovery. Current protocols for AT-MSC isolation are almost universally based on tissue dige

bms-708163 br Acknowledgements This work was supported

2018-10-20

Acknowledgements This work was supported by the IRET Foundation (2015-2016), Ozzano Emilia, Italy (no-profit organization), in the frame of the “Step-by-step” POR-FESR 2016-2020 Emilia Romagna Region project. Introduction Resident neural stem cells (NSCs) persist in the adult mammalian centra

There is now compelling evidence

2018-10-20

There is now compelling evidence indicating that both the EMP and definitive programs derive from progenitors known as hemogenic endothelial cp-690550 (HECs) that display endothelial markers and are associated with the arterial vasculature (Bertrand et al., 2005; Boisset et al., 2010; Clarke et al.,

The phenotype and fate of a given cell

2018-10-20

The phenotype and fate of a given cell relies on the precise control of gene expression by complex transcriptional and epigenetic networks. Such regulation of gene expression is essential for proper differentiation, cellular function, development, and homeostasis (Feng et al., 2010; Reik, 2007). His

Tau helps assemble and stabilize microtubules In the CNS

2018-10-20

Tau helps assemble and stabilize microtubules. In the CNS, several isoforms of tau are produced from a single gene by alternative splicing (Goedert et al., 1989). More than 40 pathogenic MAPT mutations have been described in more than 100 families with FTD (Cruts et al., 2012; Alzheimer Disease & Fr

br Introduction Cardiovascular diseases rank the first in

2018-10-20

Introduction Cardiovascular diseases rank the first in cause of death, which account for ∼30% of all deaths worldwide (Mozaffarian et al., 2015). Unlike robust cardiac regeneration observed in adult zebrafish and embryonic and neonatal mice (Porrello et al., 2011; Poss et al., 2002; Sturzu et al.

Hello world!

2018-07-29