• br Materials and methods br Results br Discussion

  2018-10-22

  

  Materials and methods Results Discussion Conclusions MesenPRO medium is not a “selective” medium that expands only the immature and/or osteogenic progenitor cells believed to reside within human alveolar periosteal tissue. However, this medium did effectively expand the population of hig

• br Experimental Procedures br Author Contributions br Acknow

  2018-10-22

  

  Experimental Procedures Author Contributions Acknowledgments Introduction In mice, combinatorial surface marker analysis has been useful in enabling direct discrimination and prospective isolation of phenotypically and functionally distinct am630 from skeletal muscle using fluorescence-

• Here we have studied the fine ultrastructure and three dimen

  2018-10-22

  

  Here we have studied the fine ultrastructure and three-dimensional (3D) organization of these invaginations and show that they correspond to envelope-limited chromatin sheets (ELCS). These structures were originally described by Davies and Small (1968) in neutrophils, and named envelope-limited shee

• br Results br Discussion Here we

  2018-10-22

  

  Results Discussion Here we established a role for HES5 in instructing a cardiac fate while repressing the hemogenic program in early mesodermal progenitors. In Hes5-KD the first hematopoietic wave of primitive erythropoiesis overrides the cardiac potential, whereas a stage-specific Hes5 overex

• In conclusion the present study

  2018-10-22

  

  In conclusion, the present study utilized an in vivo piglet model of hypoxic-preconditioning-induced ischemic tolerance to demonstrate that PC induces proliferation and neurogenesis of endogenous NSPs up to 7days after the hypoxic–ischemic insult. PC appears as a broad, non-invasive and reproducible

• br Materials and methods br Results br Discussion Recent neu

  2018-10-20

  

  Materials and methods Results Discussion Recent neurogenesis studies and the discovery of multipotent neural stem INK 128 derived from the adult mammalian CNS, including that of humans, have had a considerable influence on potential treatments for neural injury (Gross, 2000; Ming and Song,

• br Therapeutic potential of stem

  2018-10-20

  

  Therapeutic potential of stem cell replacement therapies Conclusions Author contributions Introduction Intercellular adhesion plays important role in tissue architecture and morphogenesis by controlling the assembly of individual cisapride into the three-dimensional tissues (Cavallaro a

• Immunocytochemistry Cells were fixed at room temperature wit

  2018-10-20

  

  Immunocytochemistry. Cells were fixed at room temperature with 4% paraformaldehyde for 10min. Non-specific proteins were blocked by ultra V block (Thermo). The cells were then treated with primary (RS)-CPP manufacturer overnight at 4°C. Primary antibodies were against TRA-1-60 (1:500, MA1-023, Ther

• Recent research suggests that NSCs tropism

  2018-10-20

  

  Recent research suggests that NSCs\' tropism towards neoplastic areas is driven by chemoattractants produced at the tumor site. The intratumoral hypoxic microenvironment activates SDF-1/CXCR4 and VEGF/VEGFR signaling pathways, which may act as downstream effectors to increase NSC tropism (Aboody et

• XCI is required for dosage compensation

  2018-10-20

  

  XCI is required for dosage compensation of X-linked genes in mammals (Lyon, 1961). In humans, the initiation of XCI is dependent on the X inactivation center, and the X inactive specific transcript (XIST) is a critical gene in this region, which produces a non-coding RNA and coats the X chromosome i

• br Materials and methods br Results br

  2018-10-20

  

  Materials and methods Results Discussion We have identified and begun to characterize a novel miRNA, miR-410, which on inhibition of BMP signaling by Noggin, is down-regulated in the adult SVZ. Over-expression of miR-410 in SVZ neurospheres inhibited neuronal differentiation and increased t

• sphk Although the central nervous system is relatively immun

  2018-10-20

  

  Although the central nervous system is relatively immunotolerant (Barker and Billingham, 1977) and human fetus-derived NS/PCs and hESC-derived NS/PCs (hESC-NS/PCs) showed weak immunogenicity (Odeberg et al., 2005; Åkesson et al., 2009; Liu et al., 2013a), no studies to date have investigated the ext

• A recent study indicated that

  2018-10-20

  

  A recent study indicated that XIST expression can be lost upon prolonged passaging of female hiPSCs, referred to as “erosion of XCI” (Mekhoubad et al., 2012). This epigenetic erosion was found to be irreversible and correlated with a loss of differentiation characteristics and is very relevant for d

• br Results br Discussion The first

  2018-10-20

  

  Results Discussion The first objective of this study was the definition of an optimal protocol for MSC isolation. We intentionally focused on BM and AT, as these are the most accessible tissues for MSC recovery. Current protocols for AT-MSC isolation are almost universally based on tissue dige

• bms-708163 br Acknowledgements This work was supported

  2018-10-20

  

  Acknowledgements This work was supported by the IRET Foundation (2015-2016), Ozzano Emilia, Italy (no-profit organization), in the frame of the “Step-by-step” POR-FESR 2016-2020 Emilia Romagna Region project. Introduction Resident neural stem cells (NSCs) persist in the adult mammalian centra

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