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There is now compelling evidence
2018-10-20
There is now compelling evidence indicating that both the EMP and definitive programs derive from progenitors known as hemogenic endothelial cp-690550 (HECs) that display endothelial markers and are associated with the arterial vasculature (Bertrand et al., 2005; Boisset et al., 2010; Clarke et al.,
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The phenotype and fate of a given cell
2018-10-20
The phenotype and fate of a given cell relies on the precise control of gene expression by complex transcriptional and epigenetic networks. Such regulation of gene expression is essential for proper differentiation, cellular function, development, and homeostasis (Feng et al., 2010; Reik, 2007). His
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Tau helps assemble and stabilize microtubules In the CNS
2018-10-20
Tau helps assemble and stabilize microtubules. In the CNS, several isoforms of tau are produced from a single gene by alternative splicing (Goedert et al., 1989). More than 40 pathogenic MAPT mutations have been described in more than 100 families with FTD (Cruts et al., 2012; Alzheimer Disease & Fr
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br Introduction Cardiovascular diseases rank the first in
2018-10-20
Introduction Cardiovascular diseases rank the first in cause of death, which account for ∼30% of all deaths worldwide (Mozaffarian et al., 2015). Unlike robust cardiac regeneration observed in adult zebrafish and embryonic and neonatal mice (Porrello et al., 2011; Poss et al., 2002; Sturzu et al.
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Hello world!
2018-07-29
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