• Furthermore software engineering practices are important for

  2020-08-21

  

  Furthermore, software engineering practices are important for addressing productivity problems in scientific software. Even though the speed of the hardware is rapidly increasing, the additional complexity makes it more difficult for scientists to be productive developers. According to Faulk et al.,

• Finally we have determined for the first time that

  2020-08-21

  

  Finally, we have determined for the first time that aromatase enzyme activity is necessary to observe IGF-1-dependent Microcystin-LR receptor activation. Neuroestrogen synthesis has been shown to be important for the maintenance of synaptic spine density in hippocampal slice cultures (Kretz et al.,

• In the context of E ligase drug

  2020-08-20

  

  In the context of E3 ligase drug discovery, it is critical to identify the appropriate E2/E3 substrate pairing to ensure the development and use of the most physiologically relevant screening assay. There have been many reports of limited E2/E3 activity profiling with a small number of E2 and E3 ber

• The binding of collagen X

  2020-08-20

  

  The binding of collagen X to DDR2 differs from the binding of collagen X to α2β1 integrin in that the triple helical conformation is essential for DDR2 binding. We previously reported that heat denatured pepsinised collagen X supported cell adhesion via α2β1, indicating that the triple-helical confo

• br Results and discussion A systematic search for genes enco

  2020-08-20

  

  Results and discussion A systematic search for genes encoding H+-PPases was carried out by PCR using genomic DNA from a wide range of protozoa as templates and degenerate oligonucleotides, designed from amino PFTα mg domains conserved in H+-PPases of higher plants and the proteobacterium R. rubr

• A third aim of our investigation was to evaluate the

  2020-08-20

  

  A third aim of our investigation was to evaluate the impact of the methylation profile of p15, p16, p53, and DAPK, individually or combined, on progression-free and overall survival. We did not find any statistically significant difference in progression-free survival and overall survival in MM case

• In the present study we have examined

  2020-08-20

  

  In the present study, we have examined, an alternative approach for introduction of Hyp into bacterial, non-animal collagens. Previously, Gruskin and colleagues [27] had shown that Hyp could be introduced into recombinant mammalian collagen sequences in E. coli through a mechanism of co-translation

• Our recent QTL mapping study revealed that

  2020-08-20

  

  Our recent QTL mapping study revealed that the adaptor genes, including the NCK genes and the ABI genes, are located within the genomic regions harboring the most significant QTL (Zhou et al., 2017), suggesting that these genes could be involved in the determination of resistance, and possibly throu

• There is a considerable molecular genetic heterogeneity with

  2020-08-20

  

  There is a considerable molecular genetic heterogeneity within ES/PNET. As mentioned above, either or can rearrange with in these gene fusions. Furthermore, for either gene fusion, additional heterogeneity stems from the location of the genomic breakpoints of the translocation, resulting in diffe

• The mesolimbic dopamine system is

  2020-08-19

  

  The mesolimbic dopamine system is believed to be highly important for evaluating environmental stimuli in order to generate an adaptive behavioral response. Thus, not surprisingly these functions appear to have been highly conserved across the vertebrate subphylum. Even though teleost fish lack midb

• Another important issue in biosensors is to design a simple

  2020-08-19

  

  Another important issue in biosensors is to design a simple and potable detection strategy to meet the requirement of the point-of-care (POC) test applications. According to the recent research, by using invertase RSL3 for hydrolyzing sucrose into glucose, the range of personal glucometer has been e

• The IP R is a

  2020-08-19

  

  The IP3R is a ubiquitously expressed Ca2+-release channel from the ER, activated by IP3, produced upon cellular stimulation by hormones, growth factors or neurotransmitters. Three genes are coding for the IP3R and their gene products (IP3R1, IP3R2, IP3R3) assemble in functional homo- or heterotetram

• Xenobiotic metabolism primarily occurs in liver which

  2020-08-19

  

  Xenobiotic metabolism primarily occurs in liver, which contains many enzymes to catalyze the transformation of xenobiotic. Usually, cytochrome P-450s (CYP450s) act as the first response for biotransformation of xenobiotic in organisms. CYP450s generally consist of various subfamily enzymes which can

• br Experimental br Results and discussion Fig shows schemati

  2020-08-19

  

  Experimental Results and discussion Fig. 2 shows schematically the fundamentals of the developed HRP-P4-(P4)-anti-P4-Protein-G-MBs/SPCE immunosensor. Oriented immobilization of anti-P4 was accomplished onto Protein G-MBs due to the Protein G binding ability with the Fc region of many mammals i

• br Multi hierarchical structure of

  2020-08-19

  

  Multi-hierarchical structure of collagen Protein structure is the foundation of protein functions and properties. It is generally accepted that the protein has biological function only when it has tertiary structure or above. Among the identified 28 types of collagen, most is known about type I c

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