• Dysregulation of the HPA axis resulting in alteration

  2022-09-24

  

  Dysregulation of the HPA axis, resulting in alteration to both baseline and stress-induced glucocorticoid levels (e.g., cortisol and corticosterone), has been implicated in several diseases and psychopathologies, including anxiety (McEwen et al., 2015, 2016; Shin and Liberzon, 2010). For example, ba

• In spite of decades of

  2022-09-24

  

  In spite of decades of research the mechanisms of SV endocytosis and recycling remain controversial. Accumulating evidence suggests that SV endocytosis occurs by more than one mechanism (e.g. clathrin-independent endocytosis, clathrin-mediated endocytosis, bulk endocytosis; reviewed in (Dittman and

• The first suggestion that histamine may play

  2022-09-24

  

  The first suggestion that histamine may play a role in memory consolidation was from Almeida and Izquierdo (de Almeida & Izquierdo, 1986) who showed that the immediate posttraining intracerebroventricular (i.c.v.) administration of 1–10ng of the drug were found to enhance the retention of one-trial

• It is extremely difficult to predict a plausible

  2022-09-22

  

  It is extremely difficult to predict a plausible conformer of hsGCαβ heterodimer with right orientation of multiple domains. Even though the template identities in case of dimeric domains were not high enough but still we modelled the entire heterodimeric structure of hsGCαβ with a reasonable and ju

• Cells undergoing EMT display a downregulation of E cadherin

  2022-09-22

  

  Cells undergoing EMT display a downregulation of E-cadherin and dissociation of their junctional complexes that associates cell-cell contacts with the R788 disodium cytoskeleton, known as the adherens junction (Berx and van Roy, 2009, Birchmeier and Behrens, 1994). Adherens junctions are specialized

• TRAPP Transport Protein Particle complexes share a

  2022-09-22

  

  TRAPP (Transport Protein Particle) complexes share a common core architecture and function in [Ala92]-p16 (84-103) and autophagy (Kim et al., 2016). In yeast, the core complex has GEF activity for the Rab1 ortholog Ypt1. The larger TRAPPII and III complexes include regulatory subunits implicated in

• Glutathione transferases GST have been discovered in many ti

  2022-09-22

  

  Glutathione transferases (GST) have been discovered in many tissues including the cornea of humans and several other mammals (Awasthi et al., 1980, Bilgihan et al., 2003; Gondhowiardjo and van Haeringen, 1993; Saneto et al., 1982, Sastry et al., 1995, Singh et al., 1985, Watkins et al., 1991). To da

• br Materials and methods br Results

  2022-09-22

  

  Materials and methods Results Discussion An HMC is a blinding type of cataract frequently observed in Asian countries due to the appallingly high incidence of high myopia in those areas [4], [5] and typically features earlier onset and more rapid progression of nuclear cataract [1], [2]. Th

• AFB Fapy dG has been long recognized as

  2022-09-21

  

  AFB1-Fapy-dG has been long recognized as a substrate for nucleotide excision repair [24,25]. However, we recently demonstrated that this lesion is removed by Genistein excision repair. We showed that DNA glycosylase NEIL1, a member of the Fpg/Nei glycosylase family, could excise AFB1-Fapy-dG from si

• br Materials and methods br Results br Discussion Heart hype

  2022-09-21

  

  Materials and methods Results Discussion Heart hypertrophy is initially physiological to compensate for the loss of heart functions. However, sustained stresses lead to a pathological status, in which myocardium becomes stiffened by interstitial fibrosis and thereby diastolic dysfunction in

• br Methods br Results and discussion Protein analysis

  2022-09-21

  

  Methods Results and discussion Protein analysis of commonly used cell lines (C6, D54-MG, U87, U251 and STTG1) reveals high histone methyltransferase of SXC (Cho and Bannai, 1990, Ye et al., 1999, de Groot et al., 2005, Lyons et al., 2007, Savaskan et al., 2008). Since protein expression can b

• Several studies have indicated MUC to be an effective

  2022-09-21

  

  Several studies have indicated MUC1 to be an effective marker for identifying various malignant tumors, such as gastric, breast, pancreatic, ovarian, gallbladder, uterus, lung, and prostate cancers, as well as for prognostic outcomes [16], [17], [18], [19], [20], [21], [22], [23]. Studies by Kaira e

• Indeed our immunohistochemical analysis of skin tissue sampl

  2022-09-21

  

  Indeed, our immunohistochemical analysis of skin tissue samples without any pathology confirmed the expression of MR and GR. Extending earlier findings in rats (Shaqura et al., 2016a, Shaqura et al., 2016b), we demonstrate here that MR mainly colocalize with the nociceptive neuronal marker CGRP sugg

• Our initial lead optimization started with the

  2022-09-21

  

  Our initial lead optimization started with the modification of the indole head group as summarized in . Extensive exploration indicated that there was limited tolerance of structural change in this region of the molecule. All of the modifications to the indole moiety, including N-substitution (), l

• Introduction br Alzheimer pathology A and

  2022-09-21

  

  Introduction Alzheimer pathology: Aβ and Tau Amyloid β protein (Aβ) plays an important role in AD pathogenesis. At the molecular level, senile amyloid plaques and neurofibrillary tangles (NFT) are two neuropathological hallmarks of AD [1]. Mutations in genes encoding amyloid precursor protein (A

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